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双层纳米孔的制造与应用

黄洁钰 曾兆炜 王成勇 袁志山

黄洁钰, 曾兆炜, 王成勇, 袁志山. 双层纳米孔的制造与应用[J]. 金刚石与磨料磨具工程, 2024, 44(3): 407-414. doi: 10.13394/j.cnki.jgszz.2023.0105
引用本文: 黄洁钰, 曾兆炜, 王成勇, 袁志山. 双层纳米孔的制造与应用[J]. 金刚石与磨料磨具工程, 2024, 44(3): 407-414. doi: 10.13394/j.cnki.jgszz.2023.0105
HUANG Jieyu, ZENG Zhaowei, WANG Chengyong, YUAN Zhishan. Fabrication and application of double-layer nanopore[J]. Diamond & Abrasives Engineering, 2024, 44(3): 407-414. doi: 10.13394/j.cnki.jgszz.2023.0105
Citation: HUANG Jieyu, ZENG Zhaowei, WANG Chengyong, YUAN Zhishan. Fabrication and application of double-layer nanopore[J]. Diamond & Abrasives Engineering, 2024, 44(3): 407-414. doi: 10.13394/j.cnki.jgszz.2023.0105

双层纳米孔的制造与应用

doi: 10.13394/j.cnki.jgszz.2023.0105
基金项目: 广东省自然科学基金(2021A1515012457)。
详细信息
    作者简介:

    王成勇,男,1964 年生,博士、教授、博士生导师。主要研究方向:高速加工涂层刀具制备、难加工材料的精密超精密与纳米加工理论与技术、超硬材料及其工具制造和应用技术。E-mail:cywang@gdut.edu.cn

    通讯作者:

    袁志山,男,1987 年生,博士、副教授、硕士生导师。主要研究方向:微纳制造技术与界面科学。E-mail:zhishanyuan@gdut.edu.cn

  • 中图分类号: TH77

Fabrication and application of double-layer nanopore

  • 摘要: 由于具有孔径可调节、物理化学性质稳定、极端环境适应性强、集成度高等优点,固态纳米孔逐渐成为最具潜力的单分子测序工具。在固态纳米孔发展过程中,提高其单分子检测精度一直是研究人员关注的重点。近年来,双层纳米孔受到了广泛关注。与传统的单层纳米孔相比,双层纳米孔具有的孔-腔-孔结构提供了2个分子识别位点和纳米受限空间。双孔提供的2个分子识别位点可以在单次过孔事件中获得2次目标信号,所获得的双重检测信号不仅丰富了检测信息,也为信号分析提供了最为直接的对比信息源。此外,双层孔中的空腔还可作为单分子化学反应器。因此,双层纳米孔的出现拓宽了纳米孔传感器的应用范围,在单分子检测方面具有广阔的应用前景。本文概述了纳米孔的发展历程,并重点介绍了双层纳米孔的制造方法及其在单分子检测领域的应用。

     

  • 图  1  纳米孔检测原理

    I0-基准电流,ΔI-电流变化幅值,Δt-持续时间

    Figure  1.  Schematic diagram of nanopore detection principle

    I0-Reference current,ΔI-Current variation,Δt-Lasting time

    图  2  孔-腔-孔结构[33]

    Figure  2.  Pore–cavity–pore structure[33]

    图  3  纳米孔熵笼结构[32]

    Figure  3.  Nanopore entropic cage structure[32]

    图  4  氮化硅-石墨烯双层孔结构[35]

    Figure  4.  Double-layer nanopore consisting of silicon nitride and graphene[35]

    图  5  纳米孔阵列膜-纳米孔结构[36]

    Figure  5.  Arrayed nanopore membrane - nanopore structure[36]

    图  6  堆叠孔-腔-孔结构研究λDNA分子的电泳飞行时间[30]

    Figure  6.  Time-of-flight of λDNA molecule using stacked ‘pore-cavity-pore’ device[30]

    图  7  纳米熵笼作为单分子化学反应器[32]

    Figure  7.  Entropic cages as reactors for chemically modifying single DNA molecules[32]

    图  8  双层纳米孔辅助DNA动力学校对[31]

    Figure  8.  Application of stacked pore–cavity–pore device[31]

    图  9  平面孔-腔-孔结构的应用

    Figure  9.  Application of in-plane pore–cavity–pore device

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出版历程
  • 收稿日期:  2023-05-08
  • 修回日期:  2023-05-27
  • 录用日期:  2023-06-30
  • 网络出版日期:  2024-06-28
  • 刊出日期:  2024-06-28

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